15x the Menthol. Here's Why That Matters.

The STOP MIGRAINE Science Desk
Updated October 2026 · Peer-reviewed sources
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Menthol is the part you feel. So we put in more.

The STOP MIGRAINE team · October 2026

Bar chart: typical roll-on 0.1% menthol vs STOP MIGRAINE RELIEF 1.5%

Many "migraine" roll-ons made for marketing contain around 0.1% menthol: enough to smell minty, not much more. STOP MIGRAINE RELIEF contains about 1.5%, from menthol crystals and wild mint. That's 15x the menthol.

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See the cold

Thermal-style view of the temple before and 10 seconds after applying

Menthol switches on TRPM8, your skin's cold receptor, first identified in trigeminal nerve cells. (McKemy et al., Nature, 2002) Those receptors sit in the very top layer of the skin (Dhaka et al., J Neurosci, 2008), which is why the cold arrives within seconds.

Tested where you'll use it

Menthol crystals on a scale next to the roll-on

  • Menthol on the forehead and temples: randomized, placebo-controlled migraine trial. (Borhani Haghighi et al., 2010)
  • Menthol gel at the base of the skull during migraine attacks: open-label pilot at the Jefferson Headache Center. (St Cyr et al., 2015)
  • Peppermint oil on the forehead and temples matched 1,000 mg of acetaminophen for tension-type headache. (Göbel et al., 1996)

These studies concern individual ingredients, not this product.

Where to roll it

Where to roll it: temples, base of the skull, behind the ears, back of the neck

At the first sign: temples, base of the skull, behind the ears, back of the neck. About 10 seconds. Keep it at least 1 inch away from your eyes.

More menthol. More cold. Or it's free.

Frosted roll-on: more menthol, more cold

  • 90 days to try it on real migraine days.
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  • No return. Keep the bottle.
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STOP MIGRAINE RELIEF roll-on, 10 mL

STOP MIGRAINE RELIEF

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1 Roll-On$35$35 / roll-on Most popular2 Roll-Ons$60$30 / roll-on · Save $10 Best value3 Roll-Ons$79$26.33 / roll-on · Save $26
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References

  1. Borhani Haghighi A et al. Int J Clin Pract 2010. PMID 20456191
  2. Göbel H et al. Nervenarzt 1996. PMID 8805113
  3. McKemy DD et al. Nature 2002. PMID 11882888
  4. Dhaka A et al. J Neurosci 2008. PMID 18199758
  5. Laurell K et al. Cephalalgia 2016. PMID 26643378
  6. St Cyr A et al. Front Neurol 2015. PMID 25699012

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Studies cited concern individual ingredients, not this product. Consult your healthcare provider before use if you have a medical condition, are pregnant or nursing, or take medication. For external use only. Avoid contact with eyes.