5 Reasons Women With Period Migraines Keep STOP MIGRAINE RELIEF in Their Bag

The STOP MIGRAINE Science Desk · 4 min read · 15 published studies cited

Support your body through hormonal shifts.

If your worst migraines show up like clockwork, right before or during your period, you're not imagining it. Researchers have a name for it, a hormone behind it, and a lot of data showing these attacks are tougher than the rest. Here's what the science says, and why a roll-on built for the first sign fits that week.

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1. Made for the week your body is already dealing with enough

Period migraines tend to hit when you're already exhausted, cramping and running on empty. STOP MIGRAINE RELIEF goes straight onto the skin: nothing to swallow, nothing to wait for while your stomach catches up.

Its menthol works on TRPM8, the skin's cold receptor — first identified in trigeminal nerve cells, the nerve that carries migraine pain. (McKemy et al., Nature, 2002; Peier et al., Cell, 2002) Those cold receptors sit in the very top layer of your skin, right where you roll it on. (Dhaka et al., Journal of Neuroscience, 2008)

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2. Plant-based ingredients with real research behind them

Five ingredients. No water, no fillers. And the key ones have been tested in published clinical trials:

• Menthol has been tested on the forehead and temples in a randomized, placebo-controlled migraine trial. (Borhani Haghighi et al., International Journal of Clinical Practice, 2010)
• Peppermint oil on the forehead and temples worked as well as 1,000 mg of acetaminophen for tension-type headache in a double-blind trial. (Göbel et al., Nervenarzt, 1996)
• German chamomile on the skin reduced migraine pain, nausea and light sensitivity within 30 minutes in a randomized, double-blind trial. (Zargaran et al., Neurological Sciences, 2018)
• Magnesium: in a double-blind, placebo-controlled study of women with menstrual migraine, oral magnesium taken in the second half of the cycle reduced headache days; the women also had lower magnesium levels inside their cells than controls. (Facchinetti et al., Headache, 1991 — 20 patients, oral)
• Feverfew, the classic migraine herb, rated "probably effective" for migraine prevention by the American Academy of Neurology and the American Headache Society. (Holland et al., Neurology, 2012 — oral extract)

No drowsiness. Keep taking what your doctor prescribed — this is for the first sign.

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3. It goes where hormonal migraines build

Period migraines often bring pressure across the forehead, behind the eyes, in the jaw and down the neck. You roll STOP MIGRAINE RELIEF on exactly there:

• Temples — over branches of the trigeminal nerve (Schoenen et al., Neurology, 2013; Chim et al., 2012)
• Back of the neck / base of the skull — over the greater occipital nerve, which feeds into the same pain relay as the face (Janis et al., 2010; Goadsby et al., Physiological Reviews, 2017)
• Along the jawline — for the clenching and jaw tension that come with that week

The cooling sensation starts within seconds of applying it.

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4. Easy on your worst days, wherever you are

When cramps and a migraine hit together, even getting up for a glass of water feels like too much. STOP MIGRAINE RELIEF is a 10 ml roll-on that lives on your nightstand, in your purse or in your desk drawer. One hand, about ten seconds, no mess, nothing to swallow.

And since many period migraines start with warning signs hours before the pain — yawning, a stiff neck, trouble focusing — you can keep it close and use it at the very first sign. (Laurell et al., Cephalalgia, 2016; Giffin et al., Neurology, 2003)

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5. Why your period migraine is different (and why it deserves its own plan)

This is the part most women are never told:

• It's common. In a population study of 5,000 women, about 1 in 5 women with migraine (22%) had attacks in at least half of their periods. (Vetvik et al., Cephalalgia, 2014) Across studies, menstrual migraine affects about 20–25% of women with migraine. (Vetvik & MacGregor, Lancet Neurology, 2021)
• It has an official definition. The International Classification of Headache Disorders describes "menstrual migraine" as attacks that start between 2 days before and the 3rd day of your period, in at least 2 out of 3 cycles. (ICHD-3, Cephalalgia, 2018)
• It's driven by the drop in estrogen. Attacks cluster when estrogen falls before your period, and fewer happen while estrogen is rising. (MacGregor et al., Neurology, 2006; Somerville, Neurology, 1972) Women with migraine show a faster estrogen drop before their period than women without (40% vs. 30% in two days). (Pavlović et al., Neurology, 2016) Researchers also point to prostaglandins released around menstruation. (Vetvik & MacGregor, Lancet Neurology, 2021)
• The attacks last longer. In one diary study, period migraines lasted 23.4 hours vs. 16.1 hours for other migraines. (Pinkerman & Holroyd, Cephalalgia, 2010) Another found they lasted on average 10.6 hours longer and came with severe nausea more often. (Vetvik et al., Cephalalgia, 2015)
• They respond less to usual treatment. Pain-free at 2 hours after treatment: 13.5% of menstrual attacks vs. 32.9% of other attacks. (Granella et al., Cephalalgia, 2004) They were also more likely to come back within 24 hours (36.0% vs. 19.6%). (Pinkerman & Holroyd, 2010)
• They hit harder in daily life: more impairment, longer, and more relapses than non-menstrual attacks in the same women. (MacGregor et al., Headache, 2010; Couturier et al., Cephalalgia, 2003)

That's why having something you can use early, as often as you need, without waiting on your stomach makes sense for that week.

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Studies cited concern individual ingredients or migraine in general, not this product. Consult your healthcare provider before use if you have a medical condition, are pregnant or nursing, or take medication. For external use only. Avoid contact with eyes.